ABSTRACT:
Piroxicam is an oxicam class of NSAID which is a drug of choice in the treatment of severe pains occurs in chronic diseases like osteoarthritis, rheumatoid arthritis, ankylosing spondylitis and many more severe conditions. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispercible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant. The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The solid dispersion method with piroxicam were prepared by direct solvent evaporation method using synthetic polymer which was selected though screening of three polymers. The solid dispersion were characterized by FTIR, DSC and evaluated for solubility. The orodispercible tablet of Piroxicam were formulated using homemade banana powder, Locust bean gum, Guar gum, Karaya gum as Superdisintegrant. The Tablet of piroxicam were evaluated for its physical characters, tablet hardness, weight variation test, friability, drug contents, in vitro drug release and ex-vivo drug release. The formulation F2 found to be showing good results it was optimized. It has shown lesser time in disintegration i.e., 57 Sec.
Cite this article:
Bolaj Shrivardhan Mahesh, Rayanade Pooja, Khavare Shital, Chougule Prakash. Formulation and Evaluation of Orodispersible Tablet of Piroxicam by using Natrual Polymers. Asian Journal of Pharmacy and Technology. 2025; 15(1):6-2. doi: 10.52711/2231-5713.2025.00002
Cite(Electronic):
Bolaj Shrivardhan Mahesh, Rayanade Pooja, Khavare Shital, Chougule Prakash. Formulation and Evaluation of Orodispersible Tablet of Piroxicam by using Natrual Polymers. Asian Journal of Pharmacy and Technology. 2025; 15(1):6-2. doi: 10.52711/2231-5713.2025.00002 Available on: https://ajptonline.com/AbstractView.aspx?PID=2025-15-1-2
REFERENCES:
1. Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J. Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res. 2018; 6:15.
2. Choy E. Understanding the dynamics: pathways involved in the pathogenesis of rheumatoid arthritis. Rheumatology. 2012; 51: v3–11.
3. H. Chakraborty, R. Banerjee, M. Sarkar, Biophys. Chem. 2003; 104(1): 315.
4. N.V. Chandrasekharan, H. Dai, L.T. Roos, Proc.-Natl. Acad. Sci. 2002; 99: 1392.
5. I. Ahmed, M. Aboul-Einien, In vitro and in vivo evaluation of the fast disintegrating lyophilized dry emulsion tablet containing griseofulvin, Eur. J. Pharm. Sci. 2007; 32: 58–68.
6. J. Corveleyn, S. Remon, Formulation of a lyophilized dry emulsion tablet for the delivery of poorly soluble drugs, Int. J. Pharm. 1998; 166: 65–74.
7. Amidon, G.L., Lennernas, H., Shah, V.P., Crison, J.R., A theoretical ¨ basis for a biopharmaceutic drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharm. Res. 1995; 12: 413–420.
8. Yuksel, N., Karatas, A., Ozkan, Y., Savaser, A., Ozkan, S.A., Baykara, T. Enhanced bioavailability of piroxicam using Gelucire 44/14 and Labrasol: in vitro and in vivo evaluation. Eur. J. Pharm. Biopharm. 2003; 56: 453–459
9. Okunlola A, Odeniyi MA, Arhewoh MI. Microsphere formulations of ambroxol hydrochloride: influence of Okra (Abelmoschus esculentus) mucilage as a sustained release polymer. Progress in Biomaterials. 2020 Jun; 9(1): 65-80.
10. Leuner C, Dressman J. Improving drug solubility for oral delivery using solid dispersions. European journal of Pharmaceutics and Biopharmaceutics. 2000 Jul 3; 50(1): 47-60.
11. Tung NT, Hung MV, Vo XM, Nguyen TH, Pham TM. Formulation optimization of orally disintegrating tablets containing solid dispersion of felodipine and hydroxypropyl methylcellulose using face-centered central composite design. Journal of Pharmaceutical Investigation. 2014 Apr; 44(2): 111-8.
12. Singh SY, Shirodkar RK, Verma R, Kumar L. Enhancement in dissolution rate of atorvastatin trihydrate calcium by formulating its porous tablet using sublimation technique. Journal of Pharmaceutical Innovation. 2020 Dec; 15 (4): 498-520.
13. Mushtaq M, Fazal N, Niaz A. Formulation and evaluation of fast-disintegrating tablets of flurbiprofen and metoclopramide. Journal of Pharmaceutical Innovation. 2021 Sep; 16(3): 419-38.
14. Pathan IB, Shingare PR, Kurumkar P. Formulation design and optimization of novel mouth dissolving tablets for venlafaxine hydrochloride using sublimation technique. Journal of Pharmacy Research. 2013 Jun 1; 6(6): 593-8.