Author(s): C. Parthiban, Vislavath Anjali, Vollala Supriya, Dhontam Bhanu Priya, Sadineni Sri Nithya, M. Sudhakar

Email(s): parthi1617@gmail.com

DOI: 10.52711/2231-5713.2023.00043   

Address: C. Parthiban*, Vislavath Anjali, Vollala Supriya, Dhontam Bhanu Priya, Sadineni Sri Nithya, M. Sudhakar
1Professor, Malla Reddy College of Pharmacy, Maisammaguda, Dhulapally, Secunderabad - 500100. Telangana, India.
2Department of Pharmaceutical Analysis, alla Reddy College of Pharmacy, Secunderabad - 500100, Telangana, India.
*Corresponding Author

Published In:   Volume - 13,      Issue - 4,     Year - 2023


ABSTRACT:
A simple, precise and accurate method was developed for the simultaneous estimation of memantine and donepezil. The chromatogram was performed with a Thermo scientific C18 (150 x 4.6mm, 5µm). At a flow rate of 1ml/min, mobile phase used is 70:30% v/v mixture of buffer pH 4.5 and ACN. The best detection wave length for memantine and donepezil was at 265nm. The retention time was 2.325 and 3.088minutes. Assay results of 100.87 percent and 99.31 percent, %RSD values are below 2 and linearity R2 values are 0.999 for both the drugs. The strategy appears to have been compact and worth, and it is proper for everyday Quality Control Estimates in Industry sections since Maintenance Times are Diminishing and that Gathered Code was reducing. Thus, the developed method was validated according to 1CH guidelines for routine analysis of the sample.


Cite this article:
C. Parthiban, Vislavath Anjali, Vollala Supriya, Dhontam Bhanu Priya, Sadineni Sri Nithya, M. Sudhakar. Analytical Method Development and Validation for Simultaneous Estimation of Memantine and Donepezil in Pharmaceutical Dosage form by RP-HPLC. Asian Journal of Pharmacy and Technology. 2023; 13(4):243-6. doi: 10.52711/2231-5713.2023.00043

Cite(Electronic):
C. Parthiban, Vislavath Anjali, Vollala Supriya, Dhontam Bhanu Priya, Sadineni Sri Nithya, M. Sudhakar. Analytical Method Development and Validation for Simultaneous Estimation of Memantine and Donepezil in Pharmaceutical Dosage form by RP-HPLC. Asian Journal of Pharmacy and Technology. 2023; 13(4):243-6. doi: 10.52711/2231-5713.2023.00043   Available on: https://ajptonline.com/AbstractView.aspx?PID=2023-13-4-1


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