Author(s): Harshika Singh, Shradha Singh, Pushpa Kumar, Sachin Kumar, Arjun Singh, Sonam Pathak, Alkam Khatri

Email(s): arjunphar@gmail.com

DOI: 10.52711/2231-5713.2024.00031   

Address: Harshika Singh1, Shradha Singh1, Pushpa Kumar1, Sachin Kumar1, Arjun Singh*2, Sonam Pathak1, Alkam Khatri1
1Department of Pharmacology, School of Pharmaceutical Sciences, Bhagwant University, Sikar Road, Ajmer, Rajasthan 305004, India.
2Department of Medicine, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA 19107, United States.
*Corresponding Author

Published In:   Volume - 14,      Issue - 2,     Year - 2024


ABSTRACT:
The spike protein of SARS-CoV-2, particularly its subunit Spike Protein 1 (S1), has been identified as a crucial component in the pathogenesis of COVID-19. Recent studies have revealed that SARS-CoV-2 Spike Protein 1 has the ability to activate microvascular endothelial cells, which play a vital role in maintaining vascular integrity and regulating inflammatory responses. This activation of microvascular endothelial cells by the spike protein has significant implications for COVID-19 pathogenesis. It can lead to endothelial dysfunction, increased vascular permeability, recruitment of immune cells, and the release of inflammatory molecules, contributing to the systemic inflammatory response observed in severe cases of COVID-19. Furthermore, it can exacerbate tissue damage and contribute to the cytokine storm. Understanding the mechanisms and consequences of SARS-CoV-2 Spike Protein 1-mediated activation of microvascular endothelial cells is crucial for developing targeted therapeutic interventions to mitigate the inflammatory response and improve patient outcomes. This knowledge may also guide the exploration of existing medications to modulate endothelial dysfunction and attenuate the pathogenic effects of spike protein activation. Continued research in this field is warranted to uncover precise mechanisms and develop effective strategies to combat this aspect of the disease.


Cite this article:
Harshika Singh, Shradha Singh, Pushpa Kumar, Sachin Kumar, Arjun Singh, Sonam Pathak, Alkam Khatri. Sars-Cov-2 Spike Protein 1 Activates Microvascular Endothelial Cells: Understanding the Implications. Asian Journal of Pharmacy and Technology. 2024; 14(2):179-3. doi: 10.52711/2231-5713.2024.00031

Cite(Electronic):
Harshika Singh, Shradha Singh, Pushpa Kumar, Sachin Kumar, Arjun Singh, Sonam Pathak, Alkam Khatri. Sars-Cov-2 Spike Protein 1 Activates Microvascular Endothelial Cells: Understanding the Implications. Asian Journal of Pharmacy and Technology. 2024; 14(2):179-3. doi: 10.52711/2231-5713.2024.00031   Available on: https://ajptonline.com/AbstractView.aspx?PID=2024-14-2-15


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17.    Singh, A., Rattan, S., BDNF rescues aging-associated internal anal sphincter dysfunction. American Journal of Physiology-Gastrointestinal and Liver Physiology. 2021; 321: G87–G97.
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19.    Singh, Aastha, Fatima, K., Singh, Arjun, Behl, A., Mintoo, M.J., Hasanain, M., Ashraf, R., Luqman, S., Shanker, K., Mondhe, D.M., Sarkar, J., Chanda, D., Negi, A.S., Anticancer activity and toxicity profiles of 2-benzylidene indanone lead molecule. European Journal of Pharmaceutical Sciences. 2015;  76: 57–67.
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23.    Arjun Singh. A Review of various aspects of the Ethnopharmacological, Phytochemical, Pharmacognostical, and Clinical significance of selected Medicinal plants. Asian Journal of Pharmacy and Technology. 2022; 12(4): 349-0. doi: 10.52711/2231-5713.2022.00055
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25.    Arjun Singh, Rupendra Kumar, Sachin Sharma. Natural products and Hypertension: Scope and role in Antihypertensive Therapy. Asian Journal of Nursing Education and Research. 2023; 13(2): 162-6.
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34.    Tim F. Dorweiler, Arjun Singh, Richard N Kolesnick, Julia V. Busik; Inhibition of ceramide rich platforms by anti-ceramide immunotherapy prevents retinal endothelial cell damage and the development of diabetic retinopathy. Invest. Ophthalmol. Vis. Sci. 2023; 64(8): 941.

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